Botox Treatment | Treatment Of Botulinum Poisoning

If the symptoms of botulism can be diagnosed early, a horse antitoxin, use of enemas, and extracorporeal removal of intestinal contents can be used to treat food-borne illness. Wound infections can be treated surgically. Information about methods of safe conservation and educating the public about the disease, the methods of prevention. Tests are to detect a brain scan to botulism, nerve conduction test and a Tensilon test for myasthenia gravis, botulism from other diseases in order to distinguish clearly in the same way. Electromyography (EMG) can be used to differentiate myasthenia gravis and Guillain-Barre syndrome, diseases, often mimicking botulism. Toxicity testing of serum samples, wound tissue cultures and toxicity tests and stool sample cultures are the best methods for idientifying botulism. Laboratory testing of patient serum or stool, which are then injected into mice also indicate botulism. But the quicker way to detect botulinum toxin in humans, with the mass spectrometry technology, because it reduces test time on three or four hours, while it can identify the seven types of toxin.



The fatality rate for botulinum poisoning 1950-1996 was 15.5%, compared with approximately 60% over the last 50 years. Death is usually secondary to respiratory failure due to paralysis of respiratory muscles, so treatment consists of antitoxin administration and artificial respiration, are excreted or metabolized by the neurotoxins. If initiated in time, these treatments are very effective, although antisera not affect BoNT polypeptides that have already entered cells. Occasionally, functional recovery may take several weeks to months or longer.

There are two primary botulinum antitoxin is available for the treatment of botulism. Trivalent (A, B, E) botulinum antitoxin from horses to use sources of whole antibodies (Fab & Fc portions) are derived. The antitoxin is available from the local health department via the CDC in the USA.
The second antitoxin is heptavalent (A, B, C, D, E, F, G) Botulinum Antitoxin which is derived from "despeciated" equine IgG antibodies, which had the Fc portion cleaved off leaving the F (ab ') 2 servings. This is a less immunogenic antitoxin that effective against all known strains of botulism where not contraindicated. This is from the United States Army is available. On 1 June 2006, the United States Department of Health and Human Services awarded $ 363 million contract with Cangene Group for 200,000 doses of heptavalent botulinum antitoxin over five years for the Strategic National Stockpile delivery to the beginning in 2007.